Population Pharmacokinetic/Pharmacodynamic Modeling of Depot Testosterone Cypionate in Healthy Male Subjects
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چکیده
منابع مشابه
Testosterone depot injection in male hypogonadism: a critical appraisal
Testosterone compounds have been available for almost 70 years, but the pharmaceutical formulations have been less than ideal. Traditionally, injectable testosterone esters have been used for treatment, but they generate supranormal testosterone levels shortly after the 2- to 3-weekly injection interval and then testosterone levels decline very rapidly, becoming subnormal in the days before the...
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Characterized by low serum testosterone levels and diverse symptoms, male hypogonadism is a common condition. Current medical treatment focuses on testosterone supplementation using multiple modalities such as injections, gels and pellets. Interestingly, while testosterone is considered an anabolic androgenic steroid, it has not been saddled with the social stigma that other, similar medication...
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A randomised double blind study was carried out with 50 men who had ST segment depression of 0.1 mV or more after a modified two-step exercise test. Rate and duration of exercise were the same for the last of each subject's several pretreatment tests as for his tests after 4 and 8 weeks of treatment with placebo or testosterone cypionate, 200 mg, intramuscularly weekly. The sum of ST segment d...
متن کاملPopulation variation in age-related decline in male salivary testosterone.
BACKGROUND Age-related declines in free and bioavailable testosterone are frequently reported for Western populations, but interpopulation variation in this pattern has not previously been investigated. METHODS Salivary testosterone was measured using a consistently applied protocol on morning samples collected from men in four populations (USA, Congo, Nepal, and Paraguay) representing differ...
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Lumiracoxib (Prexige; 2-[(2-fluoro-6-chlorophenyl)amino]-5-methyl-benzeneacetic acid) is a novel, chemically distinct cyclooxygenase-2 selective inhibitor, which has been developed for the treatment of osteoarthritis, rheumatoid arthritis, and acute pain. The absorption, metabolism, disposition, and mass balance of [14C]lumiracoxib were investigated in four healthy male subjects after a single ...
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ژورنال
عنوان ژورنال: CPT: Pharmacometrics & Systems Pharmacology
سال: 2018
ISSN: 2163-8306,2163-8306
DOI: 10.1002/psp4.12287